四级生物安全模式实验室设计案例分析
Case analysis of biosafety level-4 mode laboratory design
摘要：
以四级生物安全模式实验室设计为例，从关键防护设备实验环境要求、系统压力控制方法、系统消毒方式3个方面开展关键设计研究。提出在管道关键节点设置生物安全型密闭阀来保证围护结构气密性，为高效过滤装置提供试验条件；采用动态压力控制设计方法，保障实验室压力梯度稳定性，提升抗干扰能力，实现定向气流组织；采用房间单独消毒与系统消毒的双工况模式，提高实验室的使用效率，为消毒剂和消毒产品测试验证提供试验平台，满足了同时具有四级生物安全实验功能和生物安全关键防护设备试验功能的高等级生物安全实验室需求。
Abstract：
Taking the biosafety level-4 (BSL-4) mode laboratory design as an example, this paper carries out the key design research from three aspects: the experimental environment requirements of key protective equipment, system pressure control methods and system disinfection methods. It is proposed to set biosafety sealed valves at the key nodes of the air duct to ensure the tightness of the laboratory envelope and provide test conditions for high efficiency filtration units. The dynamic pressure control design method is adopted to ensure the stability of laboratory pressure gradient, improve anti-interference ability and maintain directional airflow. The dual working mode of room separate disinfection and system disinfection is adopted to improve the use efficiency of the laboratory, provide a test platform for the test and verification of disinfectants and disinfection products, and meet the needs of high-level biosafety laboratory with BSL-4 test function and biosafety key protective equipment test function at the same time.
Keywords:biosafety level-4(BSL-4) mode laboratory; tightness of envelope; pressure gradient; dynamic control; disinfection method