高等级生物安全实验室压力控制方法*
Pressure control methods in high-level biosafety laboratories
摘要：
总结了17个已建、在建或正在设计的有气密性要求的生物安全四级、大动物生物安全三级实验室所采用的压力控制方法。介绍了变送定排、定送变排、定送定排（大压差）模式的压力控制方式及其特点。分析了不同类型调节阀的选用、ⅡB2型生物安全柜的连接、风量计算和排风机选型及房间送排风形式等环节的常见问题对压力控制系统的影响。讨论了系统压力控制的稳定性、精度和智能化发展方向，为相关建设标准的修订提出了建议。
Abstract：
Summarizes the pressure control methods used in 17 high-level biosafety laboratories with air tightness requirements, including BSL-4 and BSL-3-Ag, which are established, under construction or under design. Presents air control models and their characteristics of variable air supply and constant air exhaust, constant air supply and variable air exhaust, and constant air supply and exhaust (large pressure difference). Discusses the influence of different types of valves, connection mode of ⅡB2 biosafety cabinets, air volume calculation, exhaust fan selection and the mode of indoor air supply and exhaust on the pressure control system. Discusses the development direction of stability, accuracy and intelligence of pressure control. Presents the suggestions and comments for the revision of relevant standards in the future.
Keywords:high-levelbiosafetylaboratory,airtightness,pressurecontrol,variableairvolume（VAV）,constantairvolume（CAV）